| Year |
Topic |
Title |
Authors |
N |
Journal/Presentation |
Outcome |
PMID/ Reference # |
| 2023 |
Low Back Pain |
Multimodal mechanical stimulation reduces acute and chronic low back pain: Pilot data from a HEAL phase 1 study. |
Baxter A, Thrasher A, Etnoyer-Slaski JL, Cohen LL |
20 |
Frontiers in Pain Research |
A Phase I clinical pilot investigation on a multi-motor multi-modal device was promising for drug free pain relief. Results suggested pain relief independent of thermal modality, patient age, or pain chronicity. |
NCT04494841 |
| 2019 |
Physical Therapy |
Crossover trial of novel mechanical oscillatory vibration frequency device versus TENS for musculoskeletal pain. |
Marovino T, Baxter A |
--- |
AAPM&R November 2019 |
Mean pain relief with VC high frequency vibration was 3.60 +/- 1.60 (95%CI 2.85 to 4.35). Pain relief with TENS was 1.40 +/- 1.05 (95%CI 0.91 to 1.89), with a mean difference of -2.2 +/- 1.34 (95%CI-2.85 to -1.55, P<.0001). Pain relief with VC was greatest for spine, injury and post-surgical pain (5-6) and least for OA (2-3). |
Poster 721211A |
| 2022 |
Meta Analysis |
The analgesic effect of localized vibration: a systematic review. |
Casale R, Hansson P |
--- |
Eur J Phys Rehabil Med. 2022 Apr; 58(2): 306–315. |
"Laboratory animal and human data indicate that [localized vibration] relieves pain not only by acting on the spinal gate, but also at higher levels of the nervous system." |
35102735 |
| 2017 |
Post-surgical pain |
Effect of illusory kinesthesia on hand function in patients with distal radius fractures: a quasi-randomized controlled study. |
Imai R, Osumi M et al |
22 |
Clin Rehabil. 2017 May;31(5):696-701. |
“[Tendon vibration] was an effective post-surgery management strategy not only for pain alleviation, but also hand function...with improvements persisting for up to two months.” |
28074671 |
| 2015 |
Post-surgical pain |
A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial Evaluating the Effectiveness of Daily Vibration After Arthroscopic Rotator Cuff Repair. |
Lam PH, Hansen K, et al. |
--- |
Am J Sports Med 2015 43: 2774. |
Five minutes of vibration was applied daily after arthroscopic rotator cuff repair for 6 months. Vibration did provide acute pain relief at 6 weeks after surgery (visual analog scale [VAS] score, 2.24 (0.29 cm)) compared with placebo (VAS score, 3.67 (0.48 cm)) (P=.003). |
26337247 |
| 2015 |
Immunizations |
The effect of combined stimulation of external cold and vibration during immunization on the pain and anxiety levels in children. |
Şahiner NC, Sevil I, Akbay AS. |
104 |
J Perianesth Nurs
. 2015 Jun;30(3):228-35. |
In 7 year olds getting DTAP IM, pain with Buzzy (1.31 +/- 1.36) was significantly lower than control (4.85 +/-2.72), as was anxiety (0.58 v. 1.96) all p=.001. |
26003770 |
| 2019 |
Needle Procedures |
Efficacy of the Buzzy Device for Pain Management During Needle related procedures. |
Ballard A, Khadra C, Adler, D Trottier , Bailey , Poonai N, Théroux J, Le May S. |
1138 |
Clinical Journal of Pain. Jun;35(6):532 |
Pain reduction -1.11; 95% confidence interval [CI]: -1.52 to -0.70; P<0.0001), anxiety reduction (SMD -1.37; 95% CI: -1.77 to -0.96; P<0.00001.) |
30782698 |
| 2018 |
Immunizations |
Improving vaccine-related pain, distress or fear in healthy children and adolescents - a systematic search of patient-focused interventions. |
Lee VY, Caillaud C, Fong J, Edwards KM. |
Review |
Hum Vaccin Immunother. 2018;14(11):2737 - 2747. |
"Interventions using coolant and vibration together, as well as a combination of site-specific and patient-led interventions, showed the most consistent effects in reducing self-reported pain, fear or distress." |
29792557 |
| 2021 |
Dental Injections |
Effect of vibration devices on pain associated with dental injections in children: A systematic review and meta-analysis. |
Faghihian R, Rastghalam N, Amrollahi N, Tarrahi MJ. |
Review |
Aust Dent J. 2021 Mar;66(1):4-12. |
“The findings revealed that use of DentalVibe for Paediatric dental injections was not effective in reducing pain perception. However, use of Buzzy showed promising results.” |
33258142 |
| 2021 |
Pediatrics |
Using vibrating and cold device for pain relieves in children: a systematic review and meta-analysis of randomized controlled trials. |
Su HC, Hsieh CW, Lai NM, Chou PY, Lin PH, Chen KH. |
--- |
J Pediatr Nurs. 2021 Mar 15;61:23-33. |
"Cool-vibration [Buzzy] treatment reduced pain levels in children who underwent needle procedures and the treatment appears more effective in older children. The device is promising in clinical setting due to its non-invasiveness and ease of usage." |
33735633 |
| 2023 |
Fainting |
Preventing Post-Vaccination Presyncope and Syncope in Adolescents Using Simple Clinic-Based Interventions: a Randomized-Controlled Trial |
Smith M, Walter EB et al. |
332 |
2023 Pediatric Academic Soc. Washington, DC. |
"The combination of Buzzy® and a video game decreased the risk of postvaccination presyncope by 25%, likely due to a decrease in pain." |
NCT04772755 |
| 2017 |
Blood Donation |
Effect of the Use of Buzzy during Phlebotomy on Pain and Individual Satisfaction in Blood Donors. |
Yilmaz D., Heper Y., Gözler. |
90 |
Pain Management Nursing. 2017 Aug;18(4):260-267 |
Pain reduced, satisfaction increased, adult, (p < .05) |
28601479 |
| 2018 |
Venipuncture |
Assessing the effectiveness of a thermomechanical device (Buzzy®) in reducing venous cannulation pain in adult patients. |
Abidin N, Yahya N, Izaham A, Mat W, Zain J, Zainuddin M, Mahdi S. |
184 |
Middle East Journal of Anesthesiology |
81.0% of adults satisfied with Buzzy®; N=184, Reported pain lowest with Buzzy® 33.92 ± 15.59 (p = 0.016). |
--- |
| 2011 |
Venipuncture |
An integration of vibration and cold relieves venipuncture pain in a pediatric emergency department. |
Baxter AL, Cohen LL, McElvery HL, Lawson ML, von Baeyer CL. |
81 |
Pediatr Emerg Care. |
Pain scores lower with Buzzy (-2; 95% CI, -4 to 0) than with vapocoolant (1; 95% CI, 0-2) Venipuncture success more likely with Buzzy (odds ratio, 3.05; 95% CI, 1.03-9.02), pediatric |
22134226 |
| 2021 |
Venipuncture |
Cold Vibration (Buzzy) Versus Anesthetic Patch (EMLA) for Pain Prevention during cannulation in children: A randomized trial. |
Bourdier S, Khelif N, Velasquez M, Usclada A, Rochette E et al. |
607 |
Pediatr Emerg Care. |
Children 18 months to 6 years; Time until cannulation was “effectively zero” with Buzzy. The cost of Buzzy for 1000 cannulations was equivalent to the cost of 25 EMLA patches, saving $13 per point of pain relief. |
31181022 |
| 2015 |
Venipuncture |
Effectiveness of external cold and vibration for procedural pain relief during peripheral intravenous cannulation in pediatric patients. |
Canbulat N, Ayhan F, Inal S. |
176 |
Pain Manag Nurs. |
7-12 y/o, significantly lower anxiety and pain in group using Buzzy. |
24912740 |
| 2021 |
Anesthesiology |
The Effect of Vibration on Pain During Intravenous Injection of Propofol: A Randomized Controlled Trial. |
Hwang LK, Nash DW, Yedlin A, Greige N, Larios-Valencia J, Choice C, Pothula A. |
100 |
Ann Plast Surg. 2021 Jul 1;87(1s Suppl 1):S36-S39. |
"Vibration analgesia is an effective, low-risk modality that reduces the pain of intravenous propofol injection in general anesthesia." |
33833179 |
| 2022 |
Subcutaneous Injections |
Effect of Buzzy® Application on Pain During Subcutaneous Application in Children. |
Sahin S, Ayyıldız TK |
26 |
JERN 2022; 19(3): 283-289 |
The application of Buzzy® in reducing pain in children during subcutaneous application was found to be an effective method. |
DOI:10.5152/jern.2021.82642 |
